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Data mining of microarray for differentially expressed genes in liver metastasis from gastric cancer
Ling XU MM, Feng WANG MM, Xuan-Fu XU MD, Wen-Hui MO BM, Rong WAN MD, Chuan-Yong GUO MD, Xing-Peng WANG MD,
《医学前沿(英文)》 2010年 第4卷 第2期 页码 247-253 doi: 10.1007/s11684-010-0027-4
关键词: gastric carcinoma metastasis signal transduction gene chips
null
《医学前沿(英文)》 2017年 第11卷 第1期 页码 20-31 doi: 10.1007/s11684-016-0493-4
To date, gastric carcinoma (GC) is one of the common and fatal digestive malignancies worldwide. The prognosis of GC is not always satisfactory because of late diagnosis. Scholars are keen on discovering novel accurate and economical biomarkers in body liquids for GC screening to detect and evaluate the lesion before the results of imaging techniques are obtained. While traditional serum assays have limited sensitivity and specificity, gastrointestinal juice may provide relevant specific biomarkers because of its close contact with the tumor. Herein, the current progress in the relationship between gastrointestinal fluid analyses and GC is systematically and comprehensively reviewed. The detection of gastric juice pH, fluorescence spectrum, cytology, Helicobacter pylori-associated markers, nitrosamines, conventional tumor markers, amino acids, proteomics, microRNAs, long noncoding RNAs, protein-coding genes, vitamin C, etc., and combination tests of different category markers could provide important diagnostic and prognostic clues for gastrointestinal diseases. Particularly, early GC may be efficiently screened using gastric juice. Gastrointestinal fluid examination could also predict the adverse effects of postgastrectomy, such as pancreatic leakage, fistula, and abscess. Gastric fluid markers should be further studied to reveal the early predicators of malignancy and complications. The methods for obtaining the samples of gastrointestinal juice with minimum incision should also be comprehensively investigated.
关键词: gastrointestinal fluid gastric carcinoma biomarker diagnosis prognosis gastrectomy adverse events
发生于胃和结直肠的印戒细胞癌的临床特征以及不同部位的转移对预后的预测价值的研究 Article
吴静静, 方戴琼, 满达, 吴文瑞, 王清, 李雅婷, 叶建中, 李兰娟
《工程(英文)》 2020年 第6卷 第9期 页码 1028-1034 doi: 10.1016/j.eng.2020.06.007
《环境科学与工程前沿(英文)》 2022年 第16卷 第8期 doi: 10.1007/s11783-022-1525-8
• Effect of gastric fluid on EDCs adsorption-desorption to microplastics was evaluated.
关键词: Microplastics Gastric fluid Endocrine-disrupting chemicals Adsorption Desorption
From gut changes to type 2 diabetes remission after gastric bypass surgeries
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《医学前沿(英文)》 2013年 第7卷 第2期 页码 191-200 doi: 10.1007/s11684-013-0258-2
Increasing evidence suggests that the gut may influence the host’s metabolism and ultimately change the outcomes of type 2 diabetes mellitus (T2DM). We review the evidence on the relationship between the gut and T2DM remission after gastric bypass surgery, and discuss the potential mechanisms underlying the above relationship: gut anatomical rearrangement, microbial composition changes, altered gut cells, and gut hormone modulation. However, the exact changes and their relative importance in the metabolic improvements after gastric bypass surgery remain to be further clarified. Elucidating the precise metabolic mechanisms of T2DM resolution after bypass surgery will help to reveal the molecular mechanisms of pathogenesis, and facilitate the development of novel diagnoses and preventative interventions for this common disease.
关键词: gastric bypass T2DM gut
MSI/LOH and extron expression of the FHIT gene in gastric carcinoma
XIAO Yuping, MAO Lili, HAN Chengbo, LI Jinyi, XU Lei, XIN Yan
《医学前沿(英文)》 2007年 第1卷 第1期 页码 99-103 doi: 10.1007/s11684-007-0019-1
Effect of oxytocin on gastric ischemia-reperfusion injury in rats
ZHANG Wenwen, ZHANG Jianfu, ZHANG Yongmei, XU Ming
《医学前沿(英文)》 2007年 第1卷 第4期 页码 433-437 doi: 10.1007/s11684-007-0085-4
关键词: control significant difference surgical statistical significance Sprague-Dawley
Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma and
《医学前沿(英文)》 2023年 第17卷 第1期 页码 132-142 doi: 10.1007/s11684-022-0938-x
The impact of hypoxia in hepatocellular carcinoma metastasis
null
《医学前沿(英文)》 2014年 第8卷 第1期 页码 33-41 doi: 10.1007/s11684-013-0301-3
Hypoxia is a common phenomenon in hepatocellular carcinoma (HCC). Hypoxia stabilizes transcription factor, hypoxia-inducible factor (HIF), to activate gene transcription. Expression of HIF is closely associated with metastasis and poor prognosis in HCC. HIF mediates expression of genes that are involved in every step of HCC metastasis including epithelial-mesenchymal transition, invasion of the extracellular matrix, intravasation, extravasation, and secondar y growth of the metastases. Because HIF is the central regulator of HCC metastasis, HIF inhibitors are attractive tools when used alone or as combined treatment to curb HCC metastasis. This review will summarize the current findings on the impact of hypoxia/HIF in HCC, with a particular focus on cancer metastasis.
关键词: hypoxia hepatocellular carcinoma (HCC) metastasis hypoxia-inducible factor (HIF)
Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies
null
《医学前沿(英文)》 2014年 第8卷 第1期 页码 24-32 doi: 10.1007/s11684-014-0312-8
In this review, we summarize the novel findings from our series of studies on the leading metastasis-related gene, osteopontin (OPN). In our previous gene expression profiling study, OPN was identified as one of the leading genes associated with the metastasis of hepatocellular carcinoma (HCC). We focused on OPN to evaluate its prognostic values and important roles in HCC metastasis. A retrospective study of large cohorts of HCC patients demonstrated that plasma OPN level was one of the leading independent prognostic factors for HCC patients, even in the early stage of HCC, and could serve as a surrogate serologic biomarker for monitoring the treatment response and tumor recurrence after HCC resection. Using both in vitro and in vivoinvestigations, we found that OPN has an important role in metastasis and tumor growth of HCC and is an attractive potential therapeutic target for combating HCC metastasis. We also found that OPN+ HCC cells have much more amplifications at chromosomal regions, and promoter polymorphisms are important in the regulation of OPN expression and tumor growth and lung metastasis of HCC.
关键词: osteopontin (OPN) hepatocellular carcinoma metastasis prognosis therapeutic target biomarker genetic polymorphism
null
《医学前沿(英文)》 2017年 第11卷 第4期 页码 509-521 doi: 10.1007/s11684-017-0546-3
Hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the third leading cause of cancer-related mortalities worldwide. In the last few years, treatments for HCC have significantly improved from a mere surgical resection to a series of minimally invasive therapies and targeted drugs. However, recurrence frequently occurs even upon curative therapeutics, and drug therapies generally produce disappointing results, with the overall prognosis dismal. This challenging clinical scenario warrants new effective and life-prolonging strategies for patients with HCC. Compelling evidence suggests that NK cells play a critical role in the immune function of the liver and in the immune defenses against HCC, indicating that HCC might be an ideal target for NK cell-based immunotherapies. To obtain comprehensive insights into the putative influence of NK cells on HCC, this paper summarizes current knowledge on NK cells in HCC and discusses the usefulness and prospects of NK cell-based immunotherapies. Critical issues that require consideration for the successful clinical translation of NK cell-based therapies are also addressed. If appropriately used and further optimized, NK cell-based therapies could dominate important roles in the future immunotherapeutic market of HCC.
关键词: natural killer cell hepatocellular carcinoma immunotherapy
Effect of traditional Chinese medicine combined with Western therapy on primary hepatic carcinoma: a
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《医学前沿(英文)》 2017年 第11卷 第2期 页码 191-202 doi: 10.1007/s11684-017-0512-0
Primary hepatic carcinoma (PHC) is a common malignant tumor in China. Cancer is comprehensively treated with various therapeutic regimes, including traditional Chinese medicine (TCM). TCM has been widely used to improve the quality of life, delay the time of cancer progression, and prolong the median survival time. This systematic review with meta-analysis aimed to assess the effect of TCM combined with Western therapy on primary hepatic carcinoma. A comprehensive literature search was conducted in six databases, including CNKI, VIP, Wan-Fang Database, CBM, PubMed, and Cochrane library. A total of 44 randomized controlled trials (RCTs) involving 3429 participants suffering from PHC were selected. Meta-analysis results indicated that the overall effect of TCM and Western integrative treatment on PHC was higher than that of Western intervention alone, which can postpone tumor recurrence and metastasis and prolong the overall survival time of patients with PHC. Although the obtained evidence remained weak because of the poor methodological quality of the included studies, this review provided relevant data supporting the efficacy and safety of TCM combined with Western therapies. In future research, individual RCT studies should incorporate accepted standards for trial design and reporting, proper outcome indicators according to international standards, blinding in allocation concealment, and valid follow-up periods.
关键词: traditional Chinese medicine primary hepatic carcinoma meta-analysis
Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis
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《医学前沿(英文)》 2016年 第10卷 第2期 页码 183-190 doi: 10.1007/s11684-016-0440-4
We performed weighted gene coexpression network analysis (WGCNA) to gain insights into the molecular aspects of hepatocellular carcinoma (HCC). Raw microarray datasets (including 488 samples) were downloaded from the Gene Expression Omnibus (GEO) website. Data were normalized using the RMA algorithm. We utilized the WGCNA to identify the coexpressed genes (modules) after non-specific filtering. Correlation and survival analyses were conducted using the modules, and gene ontology (GO) enrichment was applied to explore the possible mechanisms. Eight distinct modules were identified by the WGCNA. Pink and red modules were associated with liver function, whereas turquoise and black modules were inversely correlated with tumor staging. Poor outcomes were found in the low expression group in the turquoise module and in the high expression group in the red module. In addition, GO enrichment analysis suggested that inflammation, immune, virus-related, and interferon-mediated pathways were enriched in the turquoise module. Several potential biomarkers, such as cyclin-dependent kinase 1 (CDK1), topoisomerase 2α (TOP2A), and serpin peptidase inhibitor clade C (antithrombin) member 1 (SERPINC1), were also identified. In conclusion, gene signatures identified from the genome-based assays could contribute to HCC stratification. WGCNA was able to identify significant groups of genes associated with cancer prognosis.
关键词: hepatocellular carcinoma coexpression module microarray prognosis
Medical oncology management of advanced hepatocellular carcinoma 2019: a reality check
Amy Lee, Fa-Chyi Lee
《医学前沿(英文)》 2020年 第14卷 第3期 页码 273-283 doi: 10.1007/s11684-019-0728-2
关键词: hepatocellular carcinoma tyrosine kinase inhibitor check point inhibitor anti-angiogenesis
A case of primary neuroendocrine breast carcinoma that responded to neo-adjuvant chemotherapy
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《医学前沿(英文)》 2015年 第9卷 第1期 页码 112-116 doi: 10.1007/s11684-014-0345-z
Primary neuroendocrine breast carcinoma (NEBC) is a very rare type of breast cancer. Two characteristic biomarkers, namely, CgA and Syn, should be immunohistochemically detected to diagnose NEBC. In this study, a 43-year-old woman with a large mass of 8.3 cm × 2.9 cm in her right breast was reported. The patient was pathologically diagnosed with NEBC after specific markers, including CgA and Syn, as well as few differential markers, such as CK7, ER, PR, C-erbB-2, NSE, and E-cadherin, were immunohistochemically detected. The patient showed a remarkable response to four cycles of neo-adjuvant chemotherapy (partial response based on RECIST criteria) and sequentially underwent modified radical mastectomy. Moreover, the diagnosis and treatment of NEBC based on this case and available related literature were discussed.d literature were discussed.
标题 作者 时间 类型 操作
Data mining of microarray for differentially expressed genes in liver metastasis from gastric cancer
Ling XU MM, Feng WANG MM, Xuan-Fu XU MD, Wen-Hui MO BM, Rong WAN MD, Chuan-Yong GUO MD, Xing-Peng WANG MD,
期刊论文
Detection of digestive malignancies and post-gastrectomy complications via gastrointestinal fluid examination
null
期刊论文
Effect of gastric fluid on adsorption and desorption of endocrine disrupting chemicals on microplastics
期刊论文
MSI/LOH and extron expression of the FHIT gene in gastric carcinoma
XIAO Yuping, MAO Lili, HAN Chengbo, LI Jinyi, XU Lei, XIN Yan
期刊论文
Effect of oxytocin on gastric ischemia-reperfusion injury in rats
ZHANG Wenwen, ZHANG Jianfu, ZHANG Yongmei, XU Ming
期刊论文
Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies
null
期刊论文
Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic
null
期刊论文
Effect of traditional Chinese medicine combined with Western therapy on primary hepatic carcinoma: a
null
期刊论文
Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis
null
期刊论文
Medical oncology management of advanced hepatocellular carcinoma 2019: a reality check
Amy Lee, Fa-Chyi Lee
期刊论文